This unit provided support for SPARTAN Noble Team and various other Special Operations Forces during the Fall of Reach in Summer 2552. VMX-22, similar to AMX-4, primarily operates the UH-144 Falcon tiltrotor aircraft.
- This unit can trace its lineage back to the unit of the same name in the United States Marine Corps. Established in August 2003 at Marine Corps Air Station New River, this squadron is responsible for testing the MV-22B Osprey multi-mission tiltrotor aircraft, and all future aircraft of the type.
- VMX-22 is the first modern-day military unit to be featured in the Halo universe.