|This article may not meet Halo Nation's standards. You can help by cleaning this article.|
During a secretive mission taken by the UNSC Red Horse near Installation 04, the ship came across a lifepod with a single survivor nicknamed John Doe. When John Doe succumbed to his wounds Tsardikos performed an autopsy on the man. He was then assigned to Sergeant Zhao Heng Lopez's squad to search the Mona Lisa, a prisoner ship.
Once the team board the Mona Lisa they were attacked by Sangheili who had little armor. After that the team was assigned to purge the ships NAV data and Tsardikos was sent to protect the engine room. The Flood attacked causing Tsardikos to hesitate until he snapped out of it but he later died as he could not keep up with his squad.