When the time came for the Spartan augmentations, René was crippled during the surgeries and could not continue his/her military career as a Spartan-II soldier. Despite René's now defective body, Chief Petty Officer Mendez noted that René and the others who could no longer fight but still had minds, and they were reassigned to a non-combat position within the UNSC Navy, specifically planning missions, analyzing data, and troubleshooting ops.
John-117 last saw René in a neutral-buoyancy gel tank, breathing through a respirator alongside Kirk-018, whose skeletal system, due to the carbide ceramic bone ossification, was also disfigured beyond recognition like René's. René and the other injured Spartans were taken out of the launch chamber of the UNSC Atlas by a few crewman shortly after their surgical enhancements were completed. René and the others' whereabouts and positions are currently unknown, though it is likely that they were permanently reassigned to ONI as Chief Mendez had told John. It is quite possible that René has to stay in the neutral-buoyancy gel tank for the rest of their life.