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The Flood super cell can be described as a "thinking muscle" and closely resembles neurons or glial cells in structure. The Flood have demonstrated on numerous occasions that they have the ability to arrange these FSC's to mimic any organ that may be necessary. Apparently, it is also capable of intelligent discourse with Artificial intelligences, such as 032 Mendicant Bias. The Flood Infection Form use their tendrils to place this cell into any living organism, turning them into the Flood.
The Gravemind was the entity that communicated with the Forerunner AI 032 Mendicant Bias during the Forerunner-Flood war to convince it into rampancy and to turn it into a weapon against the Forerunners, using the Flood super cell to initiate communications. For a time, Mendicant Bias took faith in the Gravemind, believing the Forerunners were obstinate, unyielding, and blocking evolution's progress in the galaxy. However, after the firing of the Halo Array, Mendicant Bias realized how far he had fallen and denounced the Flood, pleading for the forgiveness of the Reclaimer in order to redeem his actions against his long-lost creators.
- The Flood Super Cell is most likely based on the 1982 film, The Thing. This alien cell is in fact a replica of what it once was; a perfect copy which can take over (via changing the cell) and mimic any other organism. The only differences are that the cell in the movie can mimic any organism perfectly. The alien can reconstruct the matter of the victim however it chooses, similar to the Flood's biomass. Also, just like the Flood, there is no known cure.
- The Thing also has Keith David (voice of The Arbiter) playing one of the American researchers in the movie.