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The Infection Spree medal resembles a skull superimposed on a blue circular background on top of a four pointed steel star; it is awarded to individuals after killing 5 humans in a row without dying in Living Dead on multiplayer matchmaking. The Infection Spree medal is the first of the infection spree medals. This medal can only be awarded on Living Dead.
- The easiest gametype to earn the Infection Spree medal in Halo: Reach is Infection as all zombies are given evade, making it harder for humans to kill zombies when they lunge forward for an infection.
- This medal can also be obtained legitimately in the Double EXP Weekend Playlist Living Dead to be viewed on Bungie.net, although you can also get this medal by playing an infection custom game with just friends and letting them get the kills.