Contents of the guide include:
- Move Out Soldier - Complete coverage of the single player missions, with labeled maps for New Mombasa and tactics included for the Legendary level of difficulty.
- Team Up - Intense Co-Op strategy to ensure you and your squadmates survive, with input from the actual developers and testers to give you the inside track.
- Clan Wisdom - All Halo 3 multiplayer maps with breakdowns and tips from some of the best clan players in the Halo Nation.
- Rise Through the Ranks - Detailed info on every Achievement from Halo 3: ODST and Halo 3. More than a list, it contains instructions and tips for every achievement.
- On the advertisement for the Halo Encyclopedia, "Halo 3: ODST" is printed as "Halo3OSDT".
- On the page describing the vehicles, the Banshee section states that an ODST cannot operate it, when it actually can be piloted in Kikowani Station.
- This strategy guide is the second shortest, after the Halo Wars: Official Strategy Guide, which is 208 pages long, and equal length as the Halo 3: The Official Strategy Guide, 209 pages also.