The Flood Containment Facility on Installation 04 was hidden deep under a swamp. During the Battle of Installation 04, it was secured initially by Covenant forces, who, upon discovering the Flood, were massacred and forced to lock down the facility. In the ensuing melee, (what appears to be) all Sangheili were either killed or infected, with only a few lances of Unggoy and Kig-Yar remaining.
Later, Captain Jacob Keyes, in desperate need of weapons to arm his troops for their potentially long guerrilla war, went to the facility with Sgt. Johnson and a part of Fire Team Charlie- previous interrogation of a Sangheili named 'Qualomee had led them to believe it was a weapons cache. After losing two Marines, the first squad, together with Captain Keyes and Johnson, continued until they found a locked door. This was probably the same door that the Covenant forces locked in order to contain the Flood outbreak. Upon opening the door, they released the infection. All team members were directly infected by the Flood except for Bisenti and Sgt. Johnson. Johnson's Boren's Syndrome, in fact referring to the effects of being a Spartan-I, prevented any sort of Flood infection. Needless to say, the routine recovery mission was tossed into utter chaos, with both Human and Covenant forces being destroyed by the horrors that had been imprisoned for countless centuries.By the time John-117 arrived at the location, the initial battle was over, with the remaining Covenant forces scattered and disorganized and the remaining Human forces holed up in the entrances, lashing out at anything that came near. The Flood itself, as if sensing a potentially new victim, quietly withdrew to the hole in which they sprang and prepared to attack their new enemy, leaving only hideous remains of their earlier killing spree. After John-117 made his way through the swamp and into the Facility, he encountered scattered Covenant, grisly remains of a terrible battle, a crazed Marine who was scared out of his mind and a single recording chip that told the entire story.
Inside the Facility a small three-man Marine fire team was found. They were the only other marines to leave the main containment building besides Sgt. Johnson. They were found by John, but were killed by the Flood.
After fighting back the Flood and making his way back to the surface, John-117 regrouped with what remained of Corporal Lovik's Second Squad and valiantly led them to the center of the swamp, fighting back Flood by the dozen. As he reached the center, the Monitor of the Installation, 343 Guilty Spark, who was patrolling the area with Sentinels in an attempt to contain the outbreak of Flood, came across John and his Marines. Identifying him as a Reclaimer, he abducted him, teleporting John away from the swamp into The Library to retrieve the Index. The remaining Marines were evacuated by ECHO-419 .
During the Heretic uprising, the Arbiter, while on the Gas Mine in the atmosphere of Threshold, came across a Flood Containment Facility which had been compromised by the Heretics. This explained the presence of Sentinels, which had previously been unexplained. The Sentinels at this facility were under the command of 343 Guilty Spark, who had escaped the Pillar of Autumn mere moments before it and Installation 04 detonated. The Flood at this Facility were presumably killed when the Facility went into free fall.
Flood Containment Facilities appear in copious locations. It is also likely that there is a Flood Containment Facility at each ring, as there was one on both Alpha Halo and Delta Halo; however, the one located on Delta Halo had a massive Flood outbreak, spawning the Halo 2 campaign missions Sacred Icon and Quarantine Zone as well as the Halo 2 multiplayer maps Lockout, Backwash and Containment.
The Halo 3 map Isolation also features contained Flood, but rather than being a Containment Facility it is instead a part of the land that has been blocked off with a small Sentinel Wall. The Halo 3 map Cold Storage is in a Cryogenic Containment Facility located on Delta Halo. The Halo Wars Skirmish map Release has a Containment Facility being overrun by the Flood, evidenced by the external Flood biomass. This facility can be exploited by the players by releasing the Flood against the opponent's base.